Pharmacologic Treatment of Low Bone Density or Osteoporosis to Prevent Fractures: A Clinical Practice Guideline from the American College of Physicians
Amir Qaseem, MD, PhD, MHA; Vincenza Snow, MD; Paul Shekelle, MD, PhD; Robert Hopkins, Jr., MD; Mary Ann Forciea, MD; and Douglas K. Owens, MD, MS, for the Clinical Efficacy Assessment Subcommittee of the American College of Physicians*
16 September 2008 Volume 149 Issue 6 Pages 404-415
Description: The American College of Physicians (ACP) developed this guideline to present the available evidence on various pharmacologic treatments to prevent fractures in men and women with low bone density or osteoporosis.
Methods: Published literature on this topic was identified by using MEDLINE (1966 to December 2006), the ACP Journal Club database, the Cochrane Central Register of Controlled Trials (no date limits), the Cochrane Database of Systematic Reviews (no date limits), Web sites of the United Kingdom National Institute of Health and Clinical Excellence (no date limits), and the United Kingdom Health Technology Assessment Program (January 1998 to December 2006). Searches were limited to English-language publications and human studies. Keywords for search included terms for osteoporosis, osteopenia, low bone density, and the drugs listed in the key questions. This guideline grades the evidence and recommendations according to the ACP's clinical practice guidelines grading system.
Recommendation 1: ACP recommends that clinicians offer pharmacologic treatment to men and women who have known osteoporosis and to those who have experienced fragility fractures (Grade: strong recommendation; high-quality evidence).
Recommendation 2: ACP recommends that clinicians consider pharmacologic treatment for men and women who are at risk for developing osteoporosis (Grade: weak recommendation; moderate-quality evidence).
Recommendation 3: ACP recommends that clinicians choose among pharmacologic treatment options for osteoporosis in men and women on the basis of an assessment of risk and benefits in individual patients (Grade: strong recommendation; moderate-quality evidence).
Recommendation 4: ACP recommends further research to evaluate treatment of osteoporosis in men and women.
Recomendaciones del Colegio América de Médicos (ACP) para el tratamiento de la osteoporosis:
Recomendación Número 1: El ACP recomienda a los médicos clínicos ofrecer tratamiento farmacológico a hombres y mujeres con diagnóstico conocido de osteoporosis o que tuvieron fracturas por fragilidad. (Grado de recomendación: fuerte y Evidencia de alta calidad).
Recomendación Número 2: El ACP recomienda a los médicos clínicos considerar el tratamiento farmacológico para los hombres y las mujeres que tienen riesgo de desarrollar osteoporosis. (Grado de evidencia débil y recomendación de calidad moderada).
Recomendación Número 3: El ACP recomienda elegir el tratamiento adecuado, según los riesgos y beneficios de cada paciente. (Grado de recomendación fuerte y calidad de evidencia moderada).
Recomendación Número 4: El ACP recomienda realizar más investigaciones que evalúen el tratamiento de la osteoporosis en hombres y mujeres. Además, sostiene que es necesario buscar estrategias de prevención e investigar sobre la duración apropiada del tratamiento.
Fuente.Qaseem A, et al. Pharmacologic treatment of Low Bone Density or Osteoporosis to prevent Fractures: A clinical Practice Guideline from the American College of Physicians
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